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Wideband MRI

From real-time biological information to functional imaging, the improved temporal/spatial resolution provided by US and JP patented Wideband MRI technology enables a wide variety of applications never before envisioned, and paves the way for fast whole-body early-stage cancer screening in the near future.

  • Faster
    • Shorter scan time
    • Combination with other acceleration techniques can push the total time reduction further.
  • Valuable
    • High patient throughput
    • Economic investment
    • High compatibility with existing MRI sequences speeds up all kinds of scans.
  • Better
    • Sub-mm spatial resolution
    • No Image quality tradeoff in Wideband MRI regardless the degree of acceleration

Faster - Mutiple images per excitation

  • Wideband MRI can dramatically reduce the MR imaging time and greatly improve the performance of MR imaging
  • More than 4 times acceleration can be achieved on our human system with Wideband 3D MRI, even 8~10 times can be obtained.
  • It is, accelerated on a dimension orthogonal to MSME and parallel imaging meaning that one can gain more speed with the combination of these methods.

Simultaneous excitation, simultaneous acquisition

Valuable - The Impact on MRI service

  • Wideband MRI is compatible to almost every existing MR sequence. It allows a direct speedup to these sequences, and to the world of MRI as well.
  • Wideband MRI is most ideal for applications obtaining large coverage such as fast large area/whole human body screening.
  • More applications in whole body screen, fMRI and Molecular imaging will easily enhance MR technology

The Impact on MRI service

Better

  • Wideband MRI provides much more information without losing SNR/contrast.
  • With Wideband MRI, 3D MR imaging is a highly efficient method for the next generation MRI
  • Wideband Isotropic 3D imaging sequence with high resolution can be available in the clinical environments

Sub-mm Isotropic brain T1 weighted image (W=3)

Full size demonstration (9.52 MB)

Resolution 0.75 mm³
Total time 13min (original ~40min)
TR 30ms
TE 7.2 ms
FOV 18 x 19 x 18 cm
Matrix size 240 x 260 x 240

Mice whole body 6 x acceleration images (W=6)

  • Total scan time: 8 min (original ~1hr)
  • Slice Positions

Full size demonstration (21.88 MB)

3D Gradient echo

Continuous volume Wideband images (W=3)

  • W=3 knee 0.5mm isotropic imaging
  • total scan time:13min (original ~40min)


Full size demonstration (23.70 MB)

Multi-lesions dynamic monitoring (W=2)

Wideband DTI

  • Applying Wideband DTI with W=2, only 1/2 excitations/acquisitions are needed for whole coverage.
  • TR can be reduced and total scan time can be cut to half.

  • Total scan time: 17min (original 35min)

eb_dti.jpg

Wideband fMRI

  • Higher spatial or temporal resolution can potentially provide more insights into the relationship between the neural activation and physiological processes.

High flexibility by using Wideband MRI

  • Wideband MRI was used to improve the spatial and temporal resolution of gradient echo imaging(GRE) in fMRI.

  • Anesthesia by α-chloralose and using forepaw electrical stimulation by 3Hz and 3mA. Repetion 120 scans and lasted 4 minutes totally.

Wideband parallel imaging

  • Wideband MRI of the human lower limb

  • a.Image and SNR of GRAPPA (R=2) only
  • b.Image and SNR of GRAPPA (R=2) with W=2 Wideband MRI
  • c.Image and SNR of GRAPPA (R=2) W=4

WonderScan 3D GRE(2X Temporal Res.)

3D Spine image (W=12)

  • W=12
  • Matrix size for each slab:50 x 60 x 353
  • Resolution:0.2 x 0.2 x 0.2 mm3
  • NEX:4
  • Total scan time:24min
  • 12 slices of each slab acquire simultaneously!!

3D Rat Spine DWI (W=6)

  • Wideband MRI can reduce 6x scan time from the conventional DTI scanning.
  • Total scan time: 27hrs → 4.5 hrs
  • Stacking-up and Rotation images

  • Null DWI

  • B = 1200 s/mm2, DWI(1,1,0)

  • DWI (1, 1, 0) with Mask

  • Validation by Anatomical Image
  • The spinal nerve L4, L5, L6 and sciatic nerves are consistent in anatomical image and MIP result.

Rat Cardiac Cine MRI (W=2)

  • WonderScan can acquire 2x higher spatial resolution rat cardiac cine MRI.
  • Spatial resolution: 260 µm2130 µm2
    • Conventional Cardiac Cine MRI (260 µm2)
    • WonderScan Cardiac Cine MRI (130 µm2)
    • (a) Full field-of-view 5.0×5.0 cm2 of rat heart.
    • (b)© Conventional and WonderScan cardiac cine MRI in the ventricular filling stage .
    • (d)(e) Conventional and WonderScan cardiac cine MRI in late diastole.
    • The conventional method spatial resolution is 260×260 µm2 and WonderScan is 130×130 µm2.
    • In the ventricular filling stage, the papillary muscle of conventional method is barely see from the image while the papillary muscle and chordae tendineae can be clearly observed in WonderScan. In the late diastolic stage, valve open is obvious in WonderScan.

Simultaneous Acquired Cerebral-Cerebellar fcMRI (W=2)

  • Simultaneous excitation and receive of multislab eliminates slice timing interpolation errors in fMRI data. figure below exhibited synchronized cerebral-cerebellar connectivity.
    • W=2
    • Matrix size for each slab:80 x 160 mm3
    • Slice thickness:0.5 mm
    • Resolution:0.3125 mm3

High-resolution Quantitative Susceptibility Mapping of Rat Brain (W=4)

    • W=4
    • Illustration of 4X-accelerated Wideband MRI. Four slabs were acquired simultaneously.
    • W=4
    • Total scan time: 96 min → 24 min
    • Comparison of 3D high-resolution (150 μm isotropic) T2* weighted magnitude image and susceptibility maps in three-orthogonal transections acquired by the W=4 accelerated Wideband MRI.
    • (A-C) Magnitude images of rat brain.
    • (D-F) Susceptibility maps of rat brain.
    • In comparison, the para- and dia-magnetic brain tissues can be differentiated by the QSM, but did not by the magnitude images.
    • (cc, corpus callosum; ac, anterior commissure; csf, cerebral spinal fluid; rrhv, rostral rhinal vein; sss, superior sagittal sinus; sts, straight sinus).

International patents

  • 6 international patents filed and more to come..

Journal papers

Conference papers

 
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