HTSC

MRI is a signal-to-noise ratio (SNR) ‘‘hungry’’ technique

Using the High Temperature Superconducting (HTS) coil can improve the SNR!!!

  • HTS surface resonator
    • Electromagnetic modelling
    • DTI of rat brain
    • Human hand imaging
  • HTS volume resonator
    • Mice whole body imaging
  • Application examples
    • DTI for a spontaneous brain tumor
    • Epilepticus-induced hippocampal injury
    • Three-week observation of vascular endothelial growth factor(VEGF)isoform 189

Superconductivity's First Century

Motivation

Theory

HTS surface resonator

  1. Electromagnetic modelling
  2. DTI of rat brain
  3. Human hand imaging

HTS volume resonator

  1. Mice whole body imaging

Application Examples

  1. DTI for a spontaneous brain tumor
  2. Epilepticus-induced hippocampal injury
  3. Three-week observation of vascular endothelial growth factor (VEGF)isoform 189

Conclusions

Honor

2006 National Innovation Award(國家新創獎):

Li-Wei Kuo, Chang-Wei Hsieh, Kai-Yuan Chen, Hsu-Lei Lee, In-Tsang Lin, Jyh-Horng Chen, “A High Performance Biotechnology Imaging System Using Magnetic Resonance Imaging with High-temperature Super-conducting Coil,” The Third Prize of The Fourth National Innovation Award, Taipei, Taiwan, 2006.

Invited magazine- “NTU Develops Prototype Bi-2223 Saddle Resonator for MRI”, Superconductor week, Vol. 26, No. 8, May 31, 2012

Publications

Journal papers

1. In-Tsang Lin, Hong-Chang Yang, Jyh-Horng Chen, ‘‘Enlargement of the field of view and maintenance of a high signal-to-noise ratio using a two-element high-Tc superconducting array in a 3T MRI”, vol. 7, issue 8, e42509, PLoS ONE, August, 2012.

2. In-Tsang Lin, Hong-Chang Yang, Jyh-Horng Chen, ‘‘Whole Body Screening Using High-Temperature Superconducting MR Volume Resonators: Mice Studies’’, vol. 7, issue 4, e33207, PLoS ONE, April, 2012.

3. In-Tsang Lin, Hong-Chang Yang, Jyh-Horng Chen, ‘‘A 4 cm High-Temperature Superconducting Surface Coil in a 3 T MRI System: Simulations and Measurements’’, IEEE Transactions on Applied Superconductivity, vol. 21, no. 6, pp.3574 - 3580, December, 2011.

4. In-Tsang Lin, Hong-Chang Yang, Jyh-Horng Chen, ‘‘Using High-Tc Superconducting Coil for Enhancement of Diffusion Tensor Imaging’’, Journal of Applied Physics, 109, 116103-pp. 1-3, June, 2011.

5. In-Tsang Lin, Hong-Chang Yang, Chang-Wei Hsieh, Tun Jao, Jyh-Horng Chen, ‘‘Human hand imaging using a 20 cm high-temperature superconducting coil in a 3T MRI system’’, Journal of Applied Physics, 107, 124701-pp. 1- 6, June, 2010, also has been selected for the July 1, 2010 issue of Virtual Journal of Applications of Superconductivity.

6. Hsu-Lei Lee, In-Tsang Lin, Jyh-Horng Chen, Herng-Er Horng, and Hong-Chang Yang, “High-Tc Superconducting Receiving Coils for Nuclear Magnetic Resonance Imaging,” IEEE Transactions on Applied Superconductivity, vol. 15, no. 2, pp.1326 - 1329, June, 2005.

Conference papers

International Conference Papers

1. Yen-Liang Liu, Yun-An Huang, In-Tsang Lin, Hong-Chang Yang, Jyh-Horng Chen, “A Brain Resting State fMRI Connectivity Study Using High-Temperature Superconducting RF Coil Platform in A 7T Rat MRI Imager”, Proc. 20th ISMRM Ann Meeting, pp. 2043, Melbourne, Australia, May 5-11, 2012. (Poster)

2. In-Tsang Lin, Hong-Chang Yang, Jyh-Horng Chen, “Diffusion Tensor Imaging using High-Tc Superconducting RF surface coil for a naturally-occurring rat brain tumor”, 28th ESMRMB Annual Scientific Meeting, pp. 685, Leipzig, Deutschland, October 6-8, 2011 (Poster)

3. In-Tsang Lin, Edzer L. Wu, Hong-Chang Yang, Jyh-Horng Chen, “HTS Volume Coil Enhanced SNR in Wideband Mice Whole Body Screening”, Proc. 19th ISMRM Ann Meeting, pp. 6410, Motreal, Quebec, May 7-13, 2011. (Poster)

4. In-Tsang Lin, Bing-Hsuan Lei, Hong-Chang Yang, Jyh-Horng Chen, “High-Temperature Superconducting RF Surface Coil Platform for In-Vivo Brain Structural Differences”, Proc. 19th ISMRM Ann Meeting, Motreal, pp. 6534, Quebec, May 7-13, 2011. (Poster)

5. In-Tsang Lin, Hong-Chang Yang, Jyh-Horng Chen, “A Long Duration High-Temperature Superconducting RF Platform”, Proc. 18th ISMRM Ann Meeting, pp. 1139, Stockholm, Sweden, May 1-7, 2010. (E-Poster)

6. In-Tsang Lin, Hong-Chang Yang, Jyh-Horng Chen, “Whole Body Screening Using High-Temperature Superconducting MR Volume Coils: Mice Studies”, Proc. 18th ISMRM Ann Meeting, pp. 925, Stockholm, Sweden, May 1-7, 2010. (E-Poster)

7. Kai-Yuan Chen, Li-Wei Kuo, In-Tsang Lin, Chang-Wei Hsieh, Hong-Chang Yang and Jyh-Horng Chen, “Design of a High-Temperature Superconducting RF Coil Platform For Rat on 3T MRI System”, World Congress on Medical Physics and Biomedical Engineering, pp. 3095, Seoul, Korea, 2006. (Poster)

8. In-Tsang Lin, Chang-Wei Hsieh, Li-Wei Kuo, Hong-Chang Yang , Herng-Er Horng, Wei-Hao Chang, Jyh-Horng Chen, ‘‘Implementation of Bi-2223 HTS tapes as RF Coils for 3T MRI System’’, Tencon 2005-2005 IEEE Region 10, Melbourne, Australia, Nov. 21-24, 2005 (Poster)

9. In-Tsang Lin, Chang-Wei Hsieh, Li-Wei Kuo, Hong-Chang Yang , Herng-Er Horng, Wei-Hao Chang, Jyh-Horng Chen, ‘‘Use of High-Tc Superconducting Tape RF Coils for Non-invasive Fiber Tracking on Diffusion Tensor MRI application’’, Tencon 2005-2005 IEEE Region 10, Melbourne, Australia, Nov. 21-24, 2005 (Poster)

10. In-Tsang Lin, Chang-Wei Hsieh, Li-Wei Kuo, Hong-Chang Yang, Jyh-Horng Chen, “Diffusion Tensor MRI Using Bi-2223 Tape RF coil”, Proc 4th Annual Meeting of The Society for Molecular Imaging, Cologne, Germany, Sep.7-10, 2005. (Poster)

11. In-Tsang Lin, Chang-Wei Hsieh, Li-Wei Kuo, Hong-Chang Yang, Ching Yao, Wei-Hao Chang, Jyh-Horng Chen, “Implementation of High-Temperature Superconducting tapes RF coils for 3T MRI system.”, Proceedings of IEEE-EMBS Conference on Biomedical Engineering, September 1-4, Shanghai, China, 2005. (Oral of Student Design Paper Competition)

12. In-Tsang Lin, Hong-Chang Yang, Chang-Wei Hsieh, Li-Wei Kuo, Ching Yao, Wei-Hao Chang, Jyh-Horng Chen, “Non-invasive Fiber Tracking on Diffusion Tensor MRI Using High-Temperature Superconducting Tape RF coil.”, Proceedings of IEEE-EMBS Conference on Biomedical Engineering, September 1-4, Shanghai, China, 2005. (Poster)

13. In-Tsang Lin, Hong-Chang Yang, Li-Wei Kuo, Chang-Wei Hsieh, Ching Yao, Wei-Hao Chang, Jyh-Horng Chen, “Diffusion Tensor MRI Using High-Temperature Superconducting Tape RF coil.”, Proc. 13th ISMRM Ann Meeting, South Beach, Miami, Florida, USA, May 2005. p.926.

14. Hsu-lei. Lee, In-Tsang Lin, Li-Wei Kuo, Hong-Chang Yang, Jyh-Horng Chen “High-Temperature Superconducting RF Coils for 3T MRI”, Proc 13th ISMRM Ann Meeting, South Beach, Miami, Florida, USA, May 2005. p942.

Domestic Conference Papers

15. In-Tsang Lin, Hong-Chang Yang, Jyh-Horng Chen, “In-Vivo MR Micro-Imaging Platform for High-Temperature Superconducting Coils”, International Symposium on Biomedical Engineering combined with the Annual Scientific Conference of Biomedical Engineering Society of R.O.C., Taipei, Taiwan, 2009, Oral, COA1.

16. In-Tsang Lin, Hong-Chang Yang, Jyh-Horng Chen, “High-Temperature Superconducting Radio Frequency Volume Coil for Mice Body Screen”, International Symposium on Biomedical Engineering combined with the Annual Scientific Conference of Biomedical Engineering Society of R.O.C., Taipei, Taiwan, 2009, Poster, PA09.

17. In-Tsang Lin, Hsu-lei. Lee, Li-Wei Kuo, Hong-Chang Yang, Jyh-Horng Chen, “High-Temperature Superconducting RF Coils for 3T MRI,” Conference on Biomedical Engineering Technology, Tainan, Taiwan, 2004, poster P-I-3.

International patents

  • 1 US patent and 1 Taiwan patent pending
 
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