Biomedical molecular imaging is the technology that successfully combined molecular biology and clinical medicine, and it will be one of potential fields of medicine in the future. Generally, there are three advantages on molecular imaging research: First, it can transform complicated processes of gene expression and signal transduction into image visually, and that one can realize the possible disease mechanism and features; Second, it’s able to find early on molecular variations of disease and the process of pathology; Last, it can in vivo observe continuously the mechanism and effect on drug or gene therapy. Biomedical molecular imaging integrated molecular biochemistry, data processing, nanotechnology and imaging processing, and then it possesses the properties of high specificity, high sensitivity and ultra-high spatial resolution. Therefore, if it used in clinical application then could really provide the data about quality, location and quantification for clinical diagnosis.


Our research

A main challenge in molecular imaging is low signal source. To acquire better MR molecular images, two major methods in our lab were utilized to enhance the sensitivity: 1. to enhance the sensitivity by MR techniques (e.g. Quantitative susceptibility mapping, home-made coil, SQUID and wideband technique); 2. to reduce the false positive rate by delievering contrast agent like Mn2+ and Fe3O4.

Quantitative susceptibility mapping (QSM)

Functional QSM in rodent

Home-made coil

Nano particle with SQUID detection

Wideband Technique

Nano particle synthesis and animal application

Integration to Pathology

Once the technical part for molecular imaging is established, we would then optimized preclinical machine parameters and apply to animal pathology model. Studies like measuring dynamic microcirculation of multiple lesion sites (WB-DCE), ADC map to evaluate chemotherapy effects of lung carcinoma; perfusion changes in Alzheimer's Disease animal are all manifest understanding toward diseases with the aid of modern molecular imaging.

Simultaneously Quantify Ktrans toward multiple lesion sites using Wideband technique

ADC map to evaluate chemotharapy in lung cancer rats

Brain activity evaluation of Alzheimer's Disease rats


趙婉婷 Wan-Ting Zhao

email: d02945007@ntu.edu.tw
topic: in vivo electrophysiology and quantitative
susceptibility mapping of trigeminal neuropathic
石家銘Chia-Ming Shih

email: stone@ibms.sinica.edu.tw
topic: MRI of tumor angiogenesis, DCE & SSCE MRI
雷秉軒Bing-Hsuan Lei

email: superbiglemon@gmail.com
topic: Activation-induced manganese-enhanced



羅新知 Hsin-Chih Lo

email: R01945015@ntu.edu.tw
topic: functional quantitative susceptibility map-
ping in rodent visual system
陳敬棠 Ching-Tang Chen

email: ferrari@me.ee.ntu.edu.tw
topic: Multi-functional MR contrast agent, Tumor
劉原甫 Yuan-Fu Liu

email: drytears@me.ee.ntu.edu.tw
topic: Xenon MRI, hyperpolarized, optical pumping


謝孟錡Meng-Chi Hsieh

topic: Quantitative susceptibility mapping algori-
thm, MEMs/ phase array coil
林巧瑩Chiao-Ying Lin

topic: Nonlinear Optical imaging, drosophila, noc-


卓冠宏Kuan-Hung Cho

topic: high angular resolution diffusion imaging,
q-ball imaging, angular resolution, hemi-spheric
al encoding scheme, cross-term correctionI
蘇家豪Chia-Hao Su

topic: Nanocontrast agents and Nanoprobes for cell
targeting and tracking, Nanomedicine for cancer
therapy, Organic synthesis


Select Journal Paper

1. Meng-Chi Hsieh, Ching-Yi Tsai, Min-Chiao Liao, Jenq-Lin Yang, Chia-Hao Su*, Jyh-Horng Chen *“Quantitative Susceptibility Mapping-Based Microscopy of Magnetic Resonance Venography (QSM-mMRV) for In Vivo Morphologically and Functionally Assessing Cerebromicrovasculature in Rat Stroke Model”. PLoS One 2016 14;11(3):e0149602. Epub 2016 Mar 14.
2. Meng-Chi Hsieh, Li-Wei Kuo, Yun-An Huang, Jyh-Horng Chen* “Investigating hyperoxic effects in the rat brain using quantitative susceptibility mapping based on MRI phase”. Magn Reson Med 2016 Feb 1. Epub 2016 Feb 1.
3. Lei BH, Chen JH*, Yin HS*. ”Repeated amphetamine treatment alters spinal magnetic resonance signals and pain sensitivity in mice”, Neurosci Lett. 2014 Nov 7;583:70-5. doi: 10.1016/j.neulet.2014.09.031. Epub 2014 Sep 22.‭ ‬
4. Chen S-M, Fan C-C, Chiue M-S, Chou C, Chen J-H*, et al. (2013) Hemodynamic and Neuropathological Analysis in Rats with Aluminum Trichloride-Induced Alzheimer's Disease. PLoS ONE 8(12): e82561. doi:10.1371/journal.pone.0082561 ‬
5. Jason Chia-Hsien Cheng, Ang Yuan, Jyh-Horng Chen, Yi-Chien Lu, Kuan-Hung Cho, Jian-Kuen Wu, Chien-Jang Wu, Yeun-Chung Chang*, Pan-Chyr Yang, ‘‘Early Detection of Lewis Lung Carcinoma Tumor Control by Irradiation Using Diffusion-Weighted and Dynamic Contrast-Enhanced MRI ”, PLoS ONE, vol.8, issue 5,e62762, May, 2013. (IF: 3.737; 7/56 in BIOLOGY)‬
6. Hsieh, W.-J, Liang, C.-J, Chieh, J.-J, Wang, S.-H, Lai, I.-R, Chen, J.-H., Chang, F.-H., Tseng, W.-K., Yang, S.-Y., Wu, C.-C., Chen, Y.-Lin,” In vivo tumor targeting and imaging with anti-vascular endothelial growth factor antibody-conjugated dextran-coated iron oxide nanoparticles”, International Journal of Nanomedicine, 2012, Volume 7, 2012, Pages 2833-2842‬
7. CH Chou, C-M Teng, K-Y Tzen, Y-C Chang, J-H Chen and JC-H Cheng, “MMP-9 from sublethally irradiated tumor promotes Lewis lung carcinoma cell invasiveness and pulmonary metastasis”, Oncogene, 2012, 31, 458–468(IF: 7.414 ; 15/185 in ONCOLOGY) ‬

Conference poster of recent 3 year

1. P.-J. Sung, M.-C. Hsieh, J.-H. Chen “A Flexible Four-channel Phased-array for Rat Cerebral Nervous System Imaging in 7T MRI” World Molecular Imaging Soc., USA 2016
2. Y.-H. Tung, W.-T. Zhao, E.L. Wu, T.-D. Chiueh, J.-H. Chen “SE-WMRI IntraGate Cardiac Imaging with Reduced Motion Artifact” World Molecular Imaging Soc., USA 2016
3. H.-C. Lo, M.-C. Hsieh, D.-Y. Chen, K. -H. Chen, J.-H. Chen “Quantitative Susceptibility Functional MRI (QS-fMRI) of Rat Brain during Flashing Light Stimulation”ICMRBS., Kyoto, 2016 (Young Investigator Award)
4. H.-C. Lo, E. L. Wu, Y.-H. Tung, M.-C. Huang,Y.-F. Chen and J.-H. Chen “Multi-Region Dynamic Contrast Enhanced MRI (DCE-MRI) Using ME-WMRI” ISMRM, USA, 2015
5. Y.-H. Tung, E. L. Wu, J.-H. Chen, “Simultaneously 9 Slabs Acquired Diffusion Tensor Imaging Saved 9x of Time,” ISMRM Workshop on Simultaneous Multi-Slice Imaging, Pacific Grove, U.S.A, July, 2015
6. W.-T. Zhao, Y.-H. Tung, P.-W. Cheng, E. L. Wu, J.-H. Chen, “Reciprocal Cerebrum-Cerebellum Communication: A Multiple Excitation Wideband Cerebellar-Limbic fcMRI Study,” ISMRM Workshop on Simultaneous Multi-Slice Imaging, Pacific Grove, U.S.A, July, 2015
7. Y.-H. Tung, Y.-A. Huang, E. L. Wu, W.-T. Zhao, T.-D. Chiueh, J.-H. Chen, “A Preliminary Study of Self-Gated Rat Cardiac Imaging by Using Wideband MRI Technique”, Proceedings of the 23th ISMRM Annual Meeting, Toronto, Canada, May 30 - June 05, 2015
8. P.-W. Cheng, Y.-H Chuang, Y.-A Huang, E. L Wu, T.-D. Chiueh, J.-H Chen “The high resolution 3D Rat Spine diffusion study by Utilizing Wideband MRI Technique”. ISMRM 23rd Annual Meeting & Exhibition, 30 May - 05 June 2015, Toronto, Ontario, Canada (E-Poster)
9. M.-C. Hsieh, Y.-A. Huang, J.-H. Chen. “Quantitative Blood Oxygen Level-dependent (qBOLD) Using Susceptibility Mapping at 7T MRI”. The 7th annual meeting of the World Molecular Imaging Congress, Seoul, Korea, September 17-20, 2014
10. Y.-H. Chuang, Y.-A. Huang, Y.-H. Tung, E. L. Wu, T.-D. Chiueh, J.-H. Chen. “A Preliminary Study of 3D Mouse Spine Diffusion Tensor Imaging by Utilizing Wideband MRI Technique”. The 7th annual meeting of the World Molecular Imaging Congress, Seoul, Korea, September 17-20, 2014
11. Y.-H. Chuang, Y.-A. Huang, E. L. Wu, T.-D. Chiueh, J.-H. Chen. “Employing Wideband MRI to Diffusion Tensor Image in Rat Brain with Higher Spatial Resolution”. The 7th annual meeting of the World Molecular Imaging Congress, Seoul, Korea, September 17-20, 2014
12. K.-W. Liang, Y.-C. Wu, Y.-A. Huang, J.-H. Chen, Y.-C. Frank Wang. “MR Image Enhancement Via Adaptive Guided Filtering”. The 36th Annual International Conference of IEEE Engineering in Medicine and Biology Society, Chicago, United States, August 26-30, 2014.
13. W.-T. Zhao, J. -H. Chen, C. -T. Yen. ''Nociceptive Thalamocortical Projection Reavealed by Manganese-Enhanced Magnetic Resonance Imaging” Annual International Conference of the IEEE Symposium on Biomedical Imaging, Beijing, China. 2014



Institutes / Labs


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